VIRAL VECTOR & GENE EDITING CORE
Adeno-Associated Vectors
Overview
About Adeno-Associated Vector (AAV) – Why it’s the platform-of-choice for preclinical and gene therapy research
Adeno-associated vector (AAV) is a ssDNA, non-pathogenic, non-harmful viral delivery system that has emerged as a superb research tool and leading platform for genetic cargo delivery in preclinical and clinical applications. Several distinct attributes make AAV the gold-standard vector for both academic and industry investigators:
- Non-Pathogenic, Non-Harmful; High Safety: AAV is not currently known to cause any disease in humans, making it a preferred choice for in vitro and in vivo delivery.
- Low Immunogenicity and Toxicity: AAV vector transduction results in a minimal immune response, supporting higher dosing, stable and long-term gene expression, and minimal off-target side effects for research-grade and clinical-grade indications.
- Broad and Modifiable Tropism: AAV can efficiently infect both dividing and non-dividing cells—which greatly fit into a broad range of applications.
- Stable, Durable and Long Term Expression: AAV vectors can drive long-term, robust and stable gene expression without integrating the transgene-of-interest into the host chromosome, such reducing safety concerns and enabling effective therapeutic outcome.
- Serotype-Driven Specificity: AAV can efficiently infect wide range of cells and tissues, and its capsids can be easily modified via serotype selection, such offering precise tissue or cell-type targeting for research use and gene therapy.
Product Information
Adeno-Associated Vector Prep Summary
|
|
|
|
| Production Time |
|
|
Small AAV preps (In Vitro Grade) | In Vitro | ≥ 5 × 10¹¹ vg/mL | 10 mL | 1 mL | 5 days | $360 | $450 |
Large AAV preps (In Vitro Grade) | In Vitro | ≥ 5 × 10¹¹ vg/mL | 100 mL | 25 mL | 5 days | $900 | $1,125 |
Small AAV Preps (In Vivo Grade) | In Vivo | ≥ 1 × 1013 vg/mL | 100 µL | 25 µL | 10 days | $660 | $825 |
Mid (Standard) AAV Preps (In Vivo Grade) | In Vivo | ≥ 1 × 1013 vg/mL | 500 µL | 100 µL | 10 days | $2,040 | $2,550 |
Large AAV Preps (In Vivo Grade) | In Vivo | ≥ 2.5 × 1013 vg/mL | 2 mL | 500 µL | 14 days | $5,976 | $7,440 |
Mega AAV Preps (In Vivo Grade) | In Vivo | ≥ 2.5 × 1013 vg/mL | 10 mL | 1 mL | 21 days |
| $20,050 |
Internal FSU user rates are available, please contact us directly for a quote.
How to Order
To connect with the IPRD Viral Vector & Gene Editing Core and place an order, simply email your request to viral.core@med.fsu.edu